|Other Names||Excitatory amino acid transporter 1, Sodium-dependent glutamate/aspartate transporter 1, GLAST-1, Solute carrier family 1 member 3, SLC1A3, EAAT1, GLAST, GLAST1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||EAAT1, GLAST, GLAST1|
|Function||Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Highly expressed in cerebellum, but also found in frontal cortex, hippocampus and basal ganglia|
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This gene encodes a member of a member of a high affinityglutamate transporter family. Mutations in this gene are associatedwith episodic ataxia, Type 6. Alternative splicing results inmultiple transcript variants.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Guilmatre, A., et al. Arch. Gen. Psychiatry 66(9):947-956(2009)Elia, J., et al. Psychiatr. Genet. 19(3):134-141(2009)Sarac, S., et al. APMIS 117(4):291-301(2009)
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