|Other Names||Tumor necrosis factor ligand superfamily member 14, Herpes virus entry mediator ligand, HVEM-L, Herpesvirus entry mediator ligand, CD258, Tumor necrosis factor ligand superfamily member 14, membrane form, Tumor necrosis factor ligand superfamily member 14, soluble form, TNFSF14, HVEML, LIGHT|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.|
|Cellular Location||Tumor necrosis factor ligand superfamily member 14, membrane form: Cell membrane; Single-pass type II membrane protein Isoform 2: Cytoplasm.|
|Tissue Location||Predominantly expressed in the spleen but also found in the brain. Weakly expressed in peripheral lymphoid tissues and in heart, placenta, liver, lung, appendix, and kidney, and no expression seen in fetal tissues, endocrine glands, or nonhematopoietic tumor lines|
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The protein encoded by this gene is a member of the tumornecrosis factor (TNF) ligand family. This protein is a ligand forTNFRSF14, which is a member of the tumor necrosis factor receptorsuperfamily, and which is also known as a herpesvirus entrymediator (HVEM). This protein may function as a costimulatoryfactor for the activation of lymphoid cells and as a deterrent toinfection by herpesvirus. This protein has been shown to stimulatethe proliferation of T cells, and trigger apoptosis of varioustumor cells. This protein is also reported to prevent tumornecrosis factor alpha mediated apoptosis in primary hepatocyte. Twoalternatively spliced transcript variant encoding distinct isoformshave been reported.
Stiles, K.M., et al. J. Virol. 84(22):11646-11660(2010)Jin, H.R., et al. Biochem. Biophys. Res. Commun. 400(4):581-586(2010)Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Cheung, T.C., et al. J. Immunol. 185(3):1949-1958(2010)Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :
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