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FST Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P19883 |
|---|---|
| Clone Names | 100507255 |
| Gene ID | 10468 |
|---|---|
| Other Names | Follistatin, FS, Activin-binding protein, FST |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | FST (HGNC:3971) |
|---|---|
| Function | Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH). |
| Cellular Location | Secreted. |
| Tissue Location | Isoform 1 is the predominant isoform in serum but is undetectable in follicular fluid. In the embryo, strong expression is seen in the palatal epithelia, including the medial edge epithelial and midline epithelial seam of the palatal shelves. Less pronounced expression is also seen throughout the palatal shelf and tongue mesenchyme (PubMed:31215115). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Follistatin is a single-chain gonadal protein thatspecifically inhibits follicle-stimulating hormone release. Thesingle FST gene encodes two isoforms, FST317 and FST344 containing317 and 344 amino acids respectively, resulting from alternativesplicing of the precursor mRNA. In a study in which 37 candidategenes were tested for linkage and association with polycystic ovarysyndrome (PCOS) or hyperandrogenemia in 150 families, evidence wasfound for linkage between PCOS and follistatin. [provided byRefSeq].
References
Chen, M.J., et al. Hum. Reprod. 25(3):779-785(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :Fajardo, M., et al. Clin. Orthop. Relat. Res. 467(12):3071-3078(2009)Bloise, E., et al. BMC Cancer 9, 320 (2009) :
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