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THEM2 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9NPJ3 |
|---|---|
| Clone Names | 70319127 |
| Gene ID | 55856 |
|---|---|
| Other Names | Acyl-coenzyme A thioesterase 13, Acyl-CoA thioesterase 13, 312-, Thioesterase superfamily member 2, Acyl-coenzyme A thioesterase 13, N-terminally processed, ACOT13, THEM2 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP1460b was selected from the C-term region of human THEM2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ACOT13 (HGNC:20999) |
|---|---|
| Synonyms | THEM2 |
| Function | Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:16934754, PubMed:19170545). Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates (By similarity) (PubMed:16934754, PubMed:19170545). Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro) (By similarity) (PubMed:16934754, PubMed:19170545). May play a role in controlling adaptive thermogenesis (By similarity). |
| Cellular Location | Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9CQR4}. Mitochondrion {ECO:0000250|UniProtKB:Q9CQR4}. Nucleus {ECO:0000250|UniProtKB:Q9CQR4} Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q9CQR4} Note=During interphase, found both in the nucleus and in the cytoplasm At mitosis, localizes to the spindle. Colocalizes with tubulin {ECO:0000250|UniProtKB:Q9CQR4} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Human thioesterase superfamily member 2 (hTHEM2) belongs to the hotdog-fold enzyme superfamily. The encoding gene is highly expressed in the kidney, and moderately expressed in the liver, brain, large intestine, and small intestine. THEM2 is essential for cell sustained proliferation based on small interference RNA silencing studies. THEM2 co-localizes with microtubules in immunostaining and GFP-Tag experiments.
References
Cheng,Z., Biochem. Biophys. Res. Commun. 350 (4), 850-853 (2006)Cheng,Z., Biochem. Biophys. Res. Commun. 349 (1), 172-177 (2006)
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