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Mouse Flt3 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q00342 |
|---|---|
| Clone Names | 110316168 |
| Gene ID | 14255 |
|---|---|
| Other Names | Receptor-type tyrosine-protein kinase FLT3, FL cytokine receptor, Fetal liver kinase 2, FLK-2, Fms-like tyrosine kinase 3, FLT-3, Tyrosine-protein kinase receptor flk-2, CD135, Flt3, Flk-2, Flt-3 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | Flt3 |
|---|---|
| Synonyms | Flk-2, Flt-3 |
| Function | Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways. |
| Cellular Location | Membrane; Single-pass type I membrane protein. Endoplasmic reticulum lumen. Note=Constitutively activated mutant forms with internal tandem duplications are less efficiently transported to the cell surface and a significant proportion is retained in an immature form in the endoplasmic reticulum lumen. The activated kinase is rapidly targeted for degradation (By similarity). |
| Tissue Location | Hematopoietic stem and progenitor cell-enriched populations. Found in brain, placenta and testis |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Flt3 is a receptor for the FL cytokine. Has a tyrosine-protein kinase activity.
References
Rathinam, C., et al. Cancer Cell 18(4):341-352(2010)DeBoy, C.A., et al. Exp. Mol. Pathol. 89(2):109-116(2010)Mkonyi, L.E., et al. Am. J. Physiol. Heart Circ. Physiol. 299 (2), H275-H283 (2010) :Carotta, S., et al. Immunity 32(5):628-641(2010)Eidenschenk, C., et al. Proc. Natl. Acad. Sci. U.S.A. 107(21):9759-9764(2010)
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