|Other Names||Receptor-type tyrosine-protein kinase FLT3, FL cytokine receptor, Fetal liver kinase 2, FLK-2, Fms-like tyrosine kinase 3, FLT-3, Tyrosine-protein kinase receptor flk-2, CD135, Flt3, Flk-2, Flt-3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.|
|Cellular Location||Membrane; Single-pass type I membrane protein. Endoplasmic reticulum lumen Note=Constitutively activated mutant forms with internal tandem duplications are less efficiently transported to the cell surface and a significant proportion is retained in an immature form in the endoplasmic reticulum lumen. The activated kinase is rapidly targeted for degradation (By similarity).|
|Tissue Location||Hematopoietic stem and progenitor cell- enriched populations. Found in brain, placenta and testis|
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Provided below are standard protocols that you may find useful for product applications.
Flt3 is a receptor for the FL cytokine. Has a tyrosine-protein kinase activity.
Rathinam, C., et al. Cancer Cell 18(4):341-352(2010)DeBoy, C.A., et al. Exp. Mol. Pathol. 89(2):109-116(2010)Mkonyi, L.E., et al. Am. J. Physiol. Heart Circ. Physiol. 299 (2), H275-H283 (2010) :Carotta, S., et al. Immunity 32(5):628-641(2010)Eidenschenk, C., et al. Proc. Natl. Acad. Sci. U.S.A. 107(21):9759-9764(2010)
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