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POLN Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q7Z5Q5
Clone Names 100120112
Peptide ID 100120112
Additional Information
Gene ID 353497
Other Names DNA polymerase nu, POLN
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name POLN
Function DNA polymerase with very low fidelity that catalyzes considerable misincorporation by inserting dTTP opposite a G template, and dGTP opposite a T template (PubMed:16787914, PubMed:17118716). Is the least accurate of the DNA polymerase A family (i.e. POLG, POLN and POLQ) (PubMed:17118716). Can perform accurate translesion DNA synthesis (TLS) past a 5S-thymine glycol. Can perform efficient strand displacement past a nick or a gap and gives rise to an amount of product similar to that on non-damaged template. Has no exonuclease activity (PubMed:16787914). Error- prone DNA polymerase that preferentially misincorporates dT regardless of template sequence (PubMed:25775266). May play a role in TLS during interstrand cross-link (ICL) repair (PubMed:19908865). May be involved in TLS when genomic replication is blocked by extremely large major groove DNA lesions. May function in the bypass of some DNA-protein and DNA-DNA cross- links. May have a role in cellular tolerance to DNA cross-linking agents (PubMed:20102227). Involved in the repair of DNA cross- links and double-strand break (DSB) resistance. Participates in FANCD2-mediated repair. Forms a complex with HELQ helicase that participates in homologous recombination (HR) repair and is essential for cellular protection against DNA cross-links (PubMed:19995904).
Cellular Location Nucleus.
Tissue Location Highly expressed in testis and heart. Weakly expressed in skeletal muscle.
Research Areas
Citations (0)

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Background

The function of this protein remains unknown.

References

Rose, J. Phd, et al. Mol. Med. (2010) In press :Yamanaka, K., et al. Chem. Res. Toxicol. 23(3):689-695(2010)Moldovan, G.L., et al. Mol. Cell. Biol. 30(4):1088-1096(2010)Zietlow, L., et al. Biochemistry 48(49):11817-11824(2009)Arana, M.E., et al. DNA Repair (Amst.) 6(2):213-223(2007)

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$ 80.00
Cat# BP14647b
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