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SLC15A2 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q16348 |
|---|---|
| Clone Names | 100318145 |
| Gene ID | 6565 |
|---|---|
| Other Names | Solute carrier family 15 member 2, Kidney H(+)/peptide cotransporter, Oligopeptide transporter, kidney isoform, Peptide transporter 2, SLC15A2, PEPT2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SLC15A2 (HGNC:10921) |
|---|---|
| Function | Proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides (PubMed:7756356, PubMed:18367661, PubMed:16434549). Transports neutral and anionic dipeptides with a proton to peptide stoichiometry of 2:1 or 3:1 (By similarity). In kidney, involved in the absorption of circulating di- and tripeptides from the glomerular filtrate (PubMed:7756356). Can also transport beta-lactam antibiotics, such as the aminocephalosporin cefadroxil, and other antiviral and anticancer drugs (PubMed:16434549). Transports the dipeptide-like aminopeptidase inhibitor bestatin (By similarity). Also able to transport carnosine (PubMed:31073693). Involved in innate immunity by promoting the detection of microbial pathogens by NOD-like receptors (NLRs) (By similarity). Mediates transport of bacterial peptidoglycans across the plasma membrane or, in macrophages, the phagosome membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand (PubMed:20406817). |
| Cellular Location | Apical cell membrane {ECO:0000250|UniProtKB:Q63424}; Multi-pass membrane protein. Cytoplasmic vesicle, phagosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Associated with the cell membrane in resting macrophages and enriched in phagocytic cups and phagosomes after particle internalization. |
| Tissue Location | Expressed in kidney (PubMed:7756356). Not detected in intestine (PubMed:7756356). Highly expressed in macrophages (PubMed:20406817). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides.
References
Man, M., et al. J Clin Pharmacol 50(8):929-940(2010)Charriere, G.M., et al. J. Biol. Chem. 285(26):20147-20154(2010)Geissler, S., et al. FEBS J. 277(3):790-795(2010)Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :Ross, C.J., et al. Nat. Genet. 41(12):1345-1349(2009)
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