|Other Names||DNA-directed RNA polymerase II subunit RPB9, RNA polymerase II subunit B9, DNA-directed RNA polymerase II subunit I, RNA polymerase II 145 kDa subunit, RPB145, POLR2I|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template (By similarity).|
|Cellular Location||Nucleus, nucleolus|
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This gene encodes a subunit of RNA polymerase II, thepolymerase responsible for synthesizing messenger RNA ineukaryotes. This subunit, in combination with two other polymerasesubunits, forms the DNA binding domain of the polymerase, a groovein which the DNA template is transcribed into RNA. The product ofthis gene has two zinc finger motifs with conserved cysteines andthe subunit does possess zinc binding activity. [provided byRefSeq].
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Grimwood, J., et al. Nature 428(6982):529-535(2004)Zhou, M., et al. Proc. Natl. Acad. Sci. U.S.A. 100(22):12666-12671(2003)Kaehlcke, K., et al. Mol. Cell 12(1):167-176(2003)Hogan, T.H., et al. Biomed. Pharmacother. 57(1):41-48(2003)
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