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RAPGEF3 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O95398
Clone Names 100525131
Peptide ID 100525131
Additional Information
Gene ID 10411
Other Names Rap guanine nucleotide exchange factor 3, Exchange factor directly activated by cAMP 1, Exchange protein directly activated by cAMP 1, EPAC 1, Rap1 guanine-nucleotide-exchange factor directly activated by cAMP, cAMP-regulated guanine nucleotide exchange factor I, cAMP-GEFI, RAPGEF3, CGEF1, EPAC, EPAC1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms CGEF1, EPAC, EPAC1
Function Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho- mediated signaling. Required for the actin rearrangement at cell- cell junctions, such as stress fibers and junctional actin.
Cellular Location Endomembrane system
Tissue Location Widely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal kidney
Research Areas
Citations (0)

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Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP.


Gloerich, M., et al. Mol. Cell. Biol. 30(22):5421-5431(2010)Rampersad, S.N., et al. J. Biol. Chem. 285(44):33614-33622(2010)Garay, J., et al. J. Immunol. 185(6):3227-3238(2010)Liu, C., et al. Mol. Cell. Biol. 30(16):3956-3969(2010)Umapathy, N.S., et al. J. Cell. Physiol. 223(1):215-223(2010)

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$ 80.00
Cat# BP14670a
Availability: In Stock
Bulk Size
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