|Other Names||Desmoglein-3, 130 kDa pemphigus vulgaris antigen, PVA, Cadherin family member 6, DSG3, CDHF6|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome|
|Tissue Location||Epidermis, tongue, tonsil, esophagus and carcinomas|
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Desmosomes are cell-cell junctions between epithelial,myocardial, and certain other cell types. Desmoglein 3 is acalcium-binding transmembrane glycoprotein component of desmosomesin vertebrate epithelial cells. Currently, three desmogleinsubfamily members have been identified and all are members of thecadherin cell adhesion molecule superfamily. These desmoglein genefamily members are located in a cluster on chromosome 18. Thisprotein has been identified as the autoantigen of the autoimmuneskin blistering disease pemphigus vulgaris.
Baican, A., et al. Int. J. Dermatol. 49(7):768-774(2010)Jolly, P.S., et al. J. Biol. Chem. 285(12):8936-8941(2010)Capon, F., et al. Br. J. Dermatol. 161(6):1403-1405(2009)Aoyama, Y., et al. Exp. Dermatol. 18(4):404-408(2009)Latourelle, J.C., et al. BMC Med. Genet. 10, 98 (2009) :
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