|Other Names||Transforming growth factor beta-1-induced transcript 1 protein, Androgen receptor coactivator 55 kDa protein, Androgen receptor-associated protein of 55 kDa, Hydrogen peroxide-inducible clone 5 protein, Hic-5, TGFB1I1, ARA55|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA- binding activity.|
|Cellular Location||Cell junction, focal adhesion. Nucleus matrix. Cytoplasm, cytoskeleton. Note=Associated with the actin cytoskeleton; colocalizes with stress fibers|
|Tissue Location||Expressed in platelets, smooth muscle and prostate stromal cells (at protein level)|
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This gene encodes a coactivator of the androgen receptor,a transcription factor which is activated by androgen and has a keyrole in male sexual differentiation. The encoded protein is thoughtto regulate androgen receptor activity and may have a role to playin the treatment of prostate cancer. Multiple transcript variantsencoding different isoforms have been found for this gene.
Inui, S., et al. J. Dermatol. Sci. 58(2):152-154(2010)Caltagarone, J., et al. J. Neuropathol. Exp. Neurol. 69(4):356-371(2010)Jones, C.A., et al. Nat. Cell Biol. 11(11):1325-1331(2009)Aghajanova, L., et al. Endocrinology 150(8):3863-3870(2009)Wang, H., et al. Oncogene 27(54):6791-6805(2008)
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