|Other Names||Fatty aldehyde dehydrogenase, Aldehyde dehydrogenase 10, Aldehyde dehydrogenase family 3 member A2, Microsomal aldehyde dehydrogenase, ALDH3A2, ALDH10, FALDH|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1468b was selected from the C-term region of human ALDH3A2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side|
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Provided below are standard protocols that you may find useful for product applications.
Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. ALDH3A2 catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acid. Mutations in the ALDH3A2 gene cause Sjogren-Larsson syndrome.
Ashibe,B., J. Biol. Chem. 282 (28), 20763-20773 (2007)Rizzo,W.B., Mol. Genet. Metab. 90 (1), 1-9 (2007)
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