|Other Names||Protein NDRG2, N-myc downstream-regulated gene 2 protein, Protein Syld709613, NDRG2, KIAA1248, SYLD|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation.|
|Cellular Location||Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone. Note=In neurons, seems to concentrate at axonal growth cone. Perinuclear in neurons (By similarity).|
|Tissue Location||Highly expressed in brain, heart, skeletal muscle and salivary gland, and moderately in kidney and liver Expressed in dendritic cells, but not in other blood cells Expression levels are low in pancreatic and liver cancer tissues; absent in meningioma. Expressed in low-grade gliomas but present at low levels in glioblastoma. Isoform 1 and isoform 2 are present in brain neurons and up-regulated in Alzheimer disease (at protein level).|
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This gene is a member of the N-myc downregulated genefamily which belongs to the alpha/beta hydrolase superfamily. Theprotein encoded by this gene is a cytoplasmic protein that may playa role in neurite outgrowth. This gene may be involved inglioblastoma carcinogenesis. Several alternatively splicedtranscript variants of this gene have been described, but thefull-length nature of some of these variants has not beendetermined.
Liu, J., et al. Exp. Cell Res. 316(12):1985-1993(2010)Choi, S.C., et al. Biochem. Biophys. Res. Commun. 396(3):684-690(2010)Shi, H., et al. Cancer Sci. 101(5):1292-1299(2010)Tschan, M.P., et al. Leuk. Res. 34(3):393-398(2010)Furuta, H., et al. Biochem. Biophys. Res. Commun. 391(4):1785-1791(2010)
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