|Other Names||Calcium-activated potassium channel subunit beta-1, BK channel subunit beta-1, BKbeta, BKbeta1, Hbeta1, Calcium-activated potassium channel, subfamily M subunit beta-1, Calcium-activated potassium channel subunit beta, Charybdotoxin receptor subunit beta-1, K(VCA)beta-1, Maxi K channel subunit beta-1, Slo-beta-1, Slo-beta, KCNMB1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Abundantly expressed in smooth muscle. Low levels of expression in most other tissues. Within the brain, relatively high levels found in hippocampus and corpus callosum|
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Provided below are standard protocols that you may find useful for product applications.
MaxiK channels are large conductance, voltage andcalcium-sensitive potassium channels which are fundamental to thecontrol of smooth muscle tone and neuronal excitability. MaxiKchannels can be formed by 2 subunits: the pore-forming alphasubunit and the product of this gene, the modulatory beta subunit.Intracellular calcium regulates the physical association betweenthe alpha and beta subunits.
Bailey, S.D., et al. Diabetes Care (2010) In press :Xie, M.J., et al. Am. J. Physiol., Cell Physiol. 298 (6), C1489-C1500 (2010) :Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :Long, X., et al. J. Biol. Chem. 284(48):33671-33682(2009)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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