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DNAJA3 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q96EY1 |
|---|---|
| Clone Names | 100525218 |
| Gene ID | 9093 |
|---|---|
| Other Names | DnaJ homolog subfamily A member 3, mitochondrial, DnaJ protein Tid-1, hTid-1, Hepatocellular carcinoma-associated antigen 57, Tumorous imaginal discs protein Tid56 homolog, DNAJA3, HCA57, TID1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | DNAJA3 |
|---|---|
| Synonyms | HCA57, TID1 |
| Function | Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway. |
| Cellular Location | Mitochondrion matrix. Cytoplasm, cytosol. Postsynaptic cell membrane; Peripheral membrane protein. Note=Recruited to the postsynaptic cell membrane of the neuromuscular junction through interaction with MUSK |
| Tissue Location | Widely expressed with highest levels in heart, liver, lung and skeletal muscles. Also expressed in keratinocytes |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
DNAJA3 belongs to the evolutionarily conserved DNAJ/HSP40family of proteins. For background information on the DNAJ family,see MIM 608375.
References
Qian, J., et al. Gastroenterology 138(4):1418-1428(2010)Kurzik-Dumke, U., et al. J Transl Med 8, 58 (2010) :Linnoila, J., et al. Neuron 60(4):625-641(2008)Kurzik-Dumke, U., et al. Int. J. Mol. Med. 21(1):19-31(2008)Kurzik-Dumke, U., et al. Cell. Signal. 19(9):1973-1985(2007)
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