|Other Names||Neuroligin-4, X-linked, Neuroligin X, HNLX, NLGN4X, KIAA1260, NLGN4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Putative neuronal cell surface protein involved in cell- cell-interactions.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density|
|Tissue Location||Expressed at highest levels in heart. Expressed at lower levels in liver, skeletal muscle and pancreas and at very low levels in brain.|
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This gene encodes a member of a family of neuronal cellsurface proteins. Members of this family may act as splicesite-specific ligands for beta-neurexins and may be involved in theformation and remodeling of central nervous system synapses. Theencoded protein interacts with discs, large (Drosophila) homolog 4(DLG4). Mutations in this gene have been associated with autism andAsperger syndrome. Two transcript variants encoding the sameprotein have been identified for this gene.
Kelemenova, S., et al. Psychiatr. Genet. 20(4):137-139(2010)Leone, P., et al. EMBO J. 29(14):2461-2471(2010)Zhang, K., et al. Neuropsychobiology 62(4):221-228(2010)Zhang, C., et al. J. Neurosci. 29(35):10843-10854(2009)Guilmatre, A., et al. Arch. Gen. Psychiatry 66(9):947-956(2009)
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