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CNOT3 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O75175
Clone Names 100517221
Peptide ID 100517221
Additional Information
Gene ID 4849
Other Names CCR4-NOT transcription complex subunit 3, CCR4-associated factor 3, Leukocyte receptor cluster member 2, CNOT3, KIAA0691, LENG2, NOT3
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CNOT3
Synonyms KIAA0691, LENG2, NOT3
Function Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of emryonic stem (ES) cell identity.
Cellular Location Cytoplasm. Nucleus. Cytoplasm, P-body. Note=NANOS2 promotes its localization to P-body.
Tissue Location Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, lung and peripheral blood leukocytes.
Research Areas
Citations (0)

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The CCR4-NOT complex functions as general transcription regulation complex.


Miyasaka, T., et al. Cancer Sci. 99(4):755-761(2008)Morita, M., et al. Mol. Cell. Biol. 27(13):4980-4990(2007)Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)Yin, X., et al. Biochem. Biophys. Res. Commun. 329(3):1010-1017(2005)Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)

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$ 80.00
Cat# BP14759a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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