|Other Names||Microtubule-associated protein RP/EB family member 2, APC-binding protein EB2, End-binding protein 2, EB2, MAPRE2, RP1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity).|
|Cellular Location||Cytoplasm, cytoskeleton. Note=Associated with the microtubule network. Accumulates at the plus end of microtubules|
|Tissue Location||Expressed in different tumor cell lines. Up- regulated in activated B- and T-lymphocytes|
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The protein encoded by this gene shares significanthomology to the adenomatous polyposis coli (APC) protein-bindingEB1 gene family. The function of this protein is unknown; however,its homology suggests involvement in tumorigenesis of colorectalcancers and proliferative control of normal cells. This gene maybelong to the intermediate/early gene family, involved in thesignal transduction cascade downstream of the TCR. Alternativesplicing results in multiple transcript variants. [provided byRefSeq].
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :De Groot, C.O., et al. J. Biol. Chem. 285(8):5802-5814(2010)Zhu, Z.C., et al. J. Biol. Chem. 284(47):32651-32661(2009)Abiatari, I., et al. Int. J. Oncol. 35(5):1111-1116(2009)Manna, T., et al. Biochemistry 47(2):779-786(2008)
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