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Mouse Dmpk Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P54265
Clone Names 110316129
Peptide ID 110316129
Additional Information
Gene ID 13400
Other Names Myotonin-protein kinase, MT-PK, DM-kinase, DMK, DMPK, Myotonic dystrophy protein kinase, MDPK, Dmpk, Dm15, Mdpk
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Dmpk
Synonyms Dm15, Mdpk
Function Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity.
Cellular Location Sarcoplasmic reticulum membrane. Cell membrane. Note=Localizes to sarcoplasmic reticulum membranes of cardiomyocytes Isoform 8: Mitochondrion outer membrane; Single-pass type IV membrane protein
Tissue Location Expressed in all tissues tested, with a predominance in brain, skeletal muscle, heart, and other tissues containing smooth muscle. In the heart, expression is restricted to the cardiomyocytes in the ventricle and atrium
Research Areas
Citations (0)

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Critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity. Phosphorylates phospholamban.


Matynia, A., et al. PLoS ONE 5 (3), E9857 (2010) :Llagostera, E., et al. FEBS Lett. 583(12):2121-2125(2009)Oude Ophuis, R.J., et al. PLoS ONE 4 (11), E8024 (2009) :Harmon, E.B., et al. Dev. Dyn. 237(9):2353-2366(2008)Dansithong, W., et al. PLoS ONE 3 (12), E3968 (2008) :

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$ 80.00
Cat# BP14773a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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