|Other Names||Multiple coagulation factor deficiency protein 2, Neural stem cell-derived neuronal survival protein, MCFD2, SDNSF|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1478a was selected from the N-term region of human MCFD2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. Plays a role in the secretion of coagulation factors.|
|Cellular Location||Endoplasmic reticulum-Golgi intermediate compartment. Endoplasmic reticulum. Golgi apparatus|
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Provided below are standard protocols that you may find useful for product applications.
The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. MCFD2 interacts in a calcium-dependent mannder with LMAN1. Defects in MCFD2 are a cause of factor V and factor VIII combined deficiency (F5F8D); also known as multiple coagulation factor deficiency 2 (MCFD2). F5F8D is an autosomal recessive bleeding disorder characterized by coordinate reduction of both clotting proteins.
Nyfeler,B., Traffic 7 (11), 1473-1481 (2006)Mohanty,D., Am. J. Hematol. 79 (4), 262-266 (2005)Zhang,B., J. Biol. Chem. 280 (27), 25881-25886 (2005)
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