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MCFD2 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8NI22
Clone Names 70319171
Additional Information
Gene ID 90411
Other Names Multiple coagulation factor deficiency protein 2, Neural stem cell-derived neuronal survival protein, MCFD2, SDNSF
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1478a was selected from the N-term region of human MCFD2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MCFD2
Synonyms SDNSF
Function The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. Plays a role in the secretion of coagulation factors.
Cellular Location Endoplasmic reticulum-Golgi intermediate compartment. Endoplasmic reticulum. Golgi apparatus
Research Areas
Citations (0)

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Background

The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. MCFD2 interacts in a calcium-dependent mannder with LMAN1. Defects in MCFD2 are a cause of factor V and factor VIII combined deficiency (F5F8D); also known as multiple coagulation factor deficiency 2 (MCFD2). F5F8D is an autosomal recessive bleeding disorder characterized by coordinate reduction of both clotting proteins.

References

Nyfeler,B., Traffic 7 (11), 1473-1481 (2006)Mohanty,D., Am. J. Hematol. 79 (4), 262-266 (2005)Zhang,B., J. Biol. Chem. 280 (27), 25881-25886 (2005)

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$ 80.00
Cat# BP1478a
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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