|Other Names||WW domain-containing oxidoreductase, 111-, Fragile site FRA16D oxidoreductase, WWOX, FOR, WOX1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||FOR, SDR41C1, WOX1|
|Function||Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.|
|Cellular Location||Cytoplasm. Nucleus. Mitochondrion. Golgi apparatus. Note=Partially localizes to the mitochondria Translocates to the nucleus upon genotoxic stress or TNF stimulation (By similarity). Translocates to the nucleus in response to TGFB1. Isoform 5 and isoform 6 may localize in the nucleus.|
|Tissue Location||Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines Isoform 5 and isoform 6 may only be expressed in tumor cell lines|
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Provided below are standard protocols that you may find useful for product applications.
WW domain-containing proteins are found in all eukaryotesand play an important role in the regulation of a wide variety ofcellular functions such as protein degradation, transcription, andRNA splicing. This gene encodes a protein which contains 2 WWdomains and a short-chain dehydrogenase/reductase domain (SRD). Thehighest normal expression of this gene is detected in hormonallyregulated tissues such as testis, ovary, and prostate. Thisexpression pattern and the presence of an SRD domain suggest a rolefor this gene in steroid metabolism. The encoded protein is morethan 90% identical to the mouse protein, which is an essentialmediator of tumor necrosis factor-alpha-induced apoptosis,suggesting a similar, important role in apoptosis for the humanprotein. In addition, there is evidence that this gene behaves as asuppressor of tumor growth. Alternative splicing of this genegenerates transcript variants that encode different isoforms.
Maeda, N., et al. Virchows Arch. 457(4):423-432(2010)Baykara, O., et al. Tumour Biol. 31(4):315-320(2010)Kurek, K.C., et al. Cancer Res. 70(13):5577-5586(2010)Lin, J., et al. Zhonghua Gan Zang Bing Za Zhi 18(5):357-360(2010)Saez, M.E., et al. BMC Med. Genet. 11, 148 (2010) :
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