|Other Names||Aldehyde dehydrogenase family 8 member A1, 121-, Aldehyde dehydrogenase 12, ALDH8A1, ALDH12|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1479b was selected from the C-term region of human ALDH8A1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Converts 9-cis-retinal to 9-cis-retinoic acid. Has lower activity towards 13-cis-retinal. Has much lower activity towards all-trans-retinal. Has highest activity with benzaldehyde and decanal (in vitro). Has a preference for NAD, but shows considerable activity with NADP (in vitro).|
|Tissue Location||Highly expressed in adult kidney and liver. Detected at lower levels in fetal liver and kidney|
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Provided below are standard protocols that you may find useful for product applications.
ALDH8A1 belongs to the aldehyde dehydrogenases family of proteins. It plays a role in a pathway of 9-cis-retinoic acid biosynthesis in vivo. This enzyme converts 9-cis-retinal into the retinoid X receptor ligand 9-cis-retinoic acid, and has approximately 40-fold higher activity with 9-cis-retinal than with all-trans-retinal. Therefore, it is the first known aldehyde dehydrogenase to show a preference for 9-cis-retinal relative to all-trans-retinal.
Lin,M.,J. Biol. Chem. 275 (51), 40106-40112 (2000)
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