|Other Names||Homeobox protein TGIF2, 5'-TG-3'-interacting factor 2, TGF-beta-induced transcription factor 2, TGFB-induced factor 2, TGIF2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins.|
|Cellular Location||Nucleus. Note=Excluded from nucleoli.|
|Tissue Location||Widely expressed. Highly expressed in heart, kidney and testis. Weakly expressed in brain and prostate|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a DNA-binding homeoboxprotein and a transcriptional repressor. The encoded proteinappears to repress transcription by recruiting histone deacetylasesto TGF beta-responsive genes. This gene is amplified andoverexpressed in some ovarian cancers, and mutations in this genecan cause holoprosencephaly.
Watanabe, T., et al. Jpn. J. Cancer Res. 93(10):1114-1122(2002)Deloukas, P., et al. Nature 414(6866):865-871(2001)Melhuish, T.A., et al. J. Biol. Chem. 276(34):32109-32114(2001)Imoto, I., et al. Biochem. Biophys. Res. Commun. 276(1):264-270(2000)
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