|Other Names||Kallikrein-15, 3421-, ACO protease, KLK15|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Protease whose physiological substrate is not yet known.|
|Tissue Location||Highest expression in the thyroid gland. Also expressed in the prostate, salivary, and adrenal glands and in the colon testis and kidney.|
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Kallikreins are a subgroup of serine proteases havingdiverse physiological functions. Growing evidence suggests thatmany kallikreins are implicated in carcinogenesis and some havepotential as novel cancer and other disease biomarkers. This geneis one of the fifteen kallikrein subfamily members located in acluster on chromosome 19. In prostate cancer, this gene hasincreased expression, which indicates its possible use as adiagnostic or prognostic marker for prostate cancer. The genecontains multiple polyadenylation sites and alternative splicingresults in multiple transcript variants encoding distinct isoforms.
Rabien, A., et al. Int. J. Cancer 127(10):2386-2394(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Han, S., et al. Hum. Immunol. 71(7):727-730(2010)Gallagher, D.J., et al. Clin. Cancer Res. 16(10):2819-2832(2010)Klein, R.J., et al. Cancer Prev Res (Phila) 3(5):611-619(2010)
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