|Other Names||Membrane progestin receptor beta, mPR beta, Lysosomal membrane protein in brain 1, Progestin and adipoQ receptor family member 8, Progestin and adipoQ receptor family member VIII, PAQR8, C6orf33, LMPB1, MPRB|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432). Seems to act through a G(i) mediated pathway (PubMed:23763432). May be involved in oocyte maturation (By similarity). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (PubMed:23161870).|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Note=Colocalizes with a lysosomal protein CTSD/cathepsin D.|
|Tissue Location||Highly expressed in the hypothalamus (PubMed:23161870). Also expressed in spinal cord, kidney and testis.|
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Provided below are standard protocols that you may find useful for product applications.
PAQR8 is steroid membrane receptor. Binds progesterone. May be involved in oocyte maturation (By similarity).
Smith, J.L., et al. Steroids 73(11):1160-1173(2008)Lamesch, P., et al. Genomics 89(3):307-315(2007)Tang, Y.T., et al. J. Mol. Evol. 61(3):372-380(2005)Mungall, A.J., et al. Nature 425(6960):805-811(2003)Hammes, S.R. Proc. Natl. Acad. Sci. U.S.A. 100(5):2168-2170(2003)
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