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LGALS9 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession O00182
Clone Names 100525239
Peptide ID 100525239
Additional Information
Gene ID 3965
Other Names Galectin-9, Gal-9, Ecalectin, Tumor antigen HOM-HD-21, LGALS9
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name LGALS9
Function Binds galactosides (PubMed:18005988). Has high affinity for the Forssman pentasaccharide (PubMed:18005988). Ligand for HAVCR2/TIM3 (PubMed:16286920). Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death (PubMed:16286920). Also stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth (By similarity). Ligand for P4HB; the interaction retains P4HB at the cell surface of Th2 T-helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307). Ligand for CD44; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up- regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity). Promotes ability of mesenchymal stromal cells to suppress T-cell proliferation (PubMed:23817958). Expands regulatory T-cells and induces cytotoxic T-cell apoptosis following virus infection (PubMed:20209097). Activates ERK1/2 phosphorylation inducing cytokine (IL-6, IL-8, IL-12) and chemokine (CCL2) production in mast and dendritic cells (PubMed:24465902, PubMed:16116184). Inhibits degranulation and induces apoptosis of mast cells (PubMed:24465902). Induces maturation and migration of dendritic cells (PubMed:25754930, PubMed:16116184). Inhibits natural killer (NK) cell function (PubMed:23408620). Can transform NK cell phenotype from peripheral to decidual during pregnancy (PubMed:25578313). Astrocyte derived galectin-9 enhances microglial TNF production (By similarity). May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. May provide the molecular basis for urate flux across cell membranes, allowing urate that is formed during purine metabolism to efflux from cells and serving as an electrogenic transporter that plays an important role in renal and gastrointestinal urate excretion (By similarity). Highly selective to the anion urate (By similarity).
Cellular Location Cytoplasm. Nucleus. Secreted Note=May also be secreted by a non-classical secretory pathway (By similarity). Secreted by mesenchymal stromal cells upon IFNG stimulation (PubMed:23817958). {ECO:0000250|UniProtKB:O08573, ECO:0000269|PubMed:23817958} Isoform 3: Secreted
Tissue Location Peripheral blood leukocytes and lymphatic tissues. Expressed in lung, liver, breast and kidney with higher levels in tumor endothelial cells than normal endothelium (at protein level) (PubMed:24333696). Expressed in trophoblast cells in decidua and placenta in pregnancy (at protein level) (PubMed:23242525, PubMed:25578313). Isoform 2 is the most abundant isoform expressed in endothelial cells (PubMed:24333696). Upon endothelial cell activation isoform 2 expression decreases while expression of isoform 3 and isoform 5 increases (PubMed:24333696) Isoform 4 decreases in pathological pregnancy (PubMed:23242525)
Research Areas
Citations (0)

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Background

The galectins are a family of beta-galactoside-bindingproteins implicated in modulating cell-cell and cell-matrixinteractions. The protein encoded by this gene is an S-type lectin.It is overexpressed in Hodgkin's disease tissue and mightparticipate in the interaction between the H&RS cells with theirsurrounding cells and might thus play a role in the pathogenesis ofthis disease and/or its associated immunodeficiency. Multiplealternatively spliced transcript variants have been found for thisgene.

References

Dardalhon, V., et al. J. Immunol. 185(3):1383-1392(2010)Tanikawa, R., et al. Biochem. Biophys. Res. Commun. 394(2):317-322(2010)Katoh, S., et al. Int. Arch. Allergy Immunol. 153(3):294-302(2010)Niki, T., et al. J. Biol. Chem. 284(47):32344-32352(2009)Zhang, F., et al. Zhonghua Zhong Liu Za Zhi 31(2):95-98(2009)

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$ 80.00
Cat# BP14853a
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