|Other Names||Galectin-9, Gal-9, Ecalectin, Tumor antigen HOM-HD-21, LGALS9|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds galactosides. Has high affinity for the Forssman pentasaccharide. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. Inhibits cell proliferation. It is a ligand for HAVCR2/TIM3. Induces T-helper type 1 lymphocyte (Th1) death. Isoform Short acts as an eosinophil chemoattractant.|
|Cellular Location||Cytoplasm. Secreted. Note=May also be secreted by a non-classical secretory pathway.|
|Tissue Location||Peripheral blood leukocytes and lymphatic tissues. Overexpressed in Hodgkin disease tissue|
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The galectins are a family of beta-galactoside-bindingproteins implicated in modulating cell-cell and cell-matrixinteractions. The protein encoded by this gene is an S-type lectin.It is overexpressed in Hodgkin's disease tissue and mightparticipate in the interaction between the H&RS cells with theirsurrounding cells and might thus play a role in the pathogenesis ofthis disease and/or its associated immunodeficiency. Multiplealternatively spliced transcript variants have been found for thisgene.
Dardalhon, V., et al. J. Immunol. 185(3):1383-1392(2010)Tanikawa, R., et al. Biochem. Biophys. Res. Commun. 394(2):317-322(2010)Katoh, S., et al. Int. Arch. Allergy Immunol. 153(3):294-302(2010)Niki, T., et al. J. Biol. Chem. 284(47):32344-32352(2009)Zhang, F., et al. Zhonghua Zhong Liu Za Zhi 31(2):95-98(2009)
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