|Other Names||Kinesin-like protein KIF23, Kinesin-like protein 5, Mitotic kinesin-like protein 1, KIF23, KNSL5, MKLP1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro.|
|Cellular Location||Nucleus. Cytoplasm, cytoskeleton, spindle. Midbody. Note=Localizes to the interzone of mitotic spindles Detected at the midbody during later stages of mitotic cytokinesis|
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The protein encoded by this gene is a member ofkinesin-like protein family. This family includesmicrotubule-dependent molecular motors that transport organelleswithin cells and move chromosomes during cell division. Thisprotein has been shown to cross-bridge antiparallel microtubulesand drive microtubule movement in vitro. Alternate splicing of thisgene results in two transcript variants encoding two differentisoforms.
Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :Douglas, M.E., et al. Curr. Biol. 20(10):927-933(2010)Seguin, L., et al. Mol. Cell. Biol. 29(2):570-581(2009)Pohl, C., et al. Cell 132(5):832-845(2008)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
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