|Other Names||Regulator of G-protein signaling 5, RGS5, RGS5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha (By similarity).|
|Cellular Location||Isoform 1: Cytoplasm. Membrane|
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This gene encodes a member of the regulators of G proteinsignaling (RGS) family. The RGS proteins are signal transductionmolecules which are involved in the regulation of heterotrimeric Gproteins by acting as GTPase activators. This gene is ahypoxia-inducible factor-1 dependent, hypoxia-induced gene which isinvolved in the induction of endothelial apoptosis. This gene isalso one of three genes on chromosome 1q contributing to elevatedblood pressure. Alternatively spliced transcript variants encodingdifferent isoforms have been identified.
Wang, J., et al. Carcinogenesis 31(10):1755-1761(2010)Li, H., et al. Proc. Natl. Acad. Sci. U.S.A. 107(31):13818-13823(2010)Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Xiao, B., et al. Clin. Chem. Lab. Med. 47(12):1483-1488(2009)
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