RGS5 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O15539 |
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Clone Names | 100525316 |
Gene ID | 8490 |
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Other Names | Regulator of G-protein signaling 5, RGS5, RGS5 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | RGS5 |
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Function | Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha (By similarity). |
Cellular Location | [Isoform 1]: Cytoplasm. Membrane |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the regulators of G proteinsignaling (RGS) family. The RGS proteins are signal transductionmolecules which are involved in the regulation of heterotrimeric Gproteins by acting as GTPase activators. This gene is ahypoxia-inducible factor-1 dependent, hypoxia-induced gene which isinvolved in the induction of endothelial apoptosis. This gene isalso one of three genes on chromosome 1q contributing to elevatedblood pressure. Alternatively spliced transcript variants encodingdifferent isoforms have been identified.
References
Wang, J., et al. Carcinogenesis 31(10):1755-1761(2010)Li, H., et al. Proc. Natl. Acad. Sci. U.S.A. 107(31):13818-13823(2010)Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Xiao, B., et al. Clin. Chem. Lab. Med. 47(12):1483-1488(2009)
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