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TADA2L Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession O75478
Clone Names 100528096
Peptide ID 100528096
Additional Information
Other Names Transcriptional adapter 2-alpha, Transcriptional adapter 2-like, ADA2-like protein, TADA2A, TADA2L
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TADA2A
Synonyms TADA2L
Function Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double- stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity (PubMed:22644376). May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage (PubMed:22644376).
Cellular Location Nucleus. Chromosome {ECO:0000250|UniProtKB:Q8CHV6}
Tissue Location Expressed in all tissues, but most abundantly in testis EMBL; AF064094; AAC26659.1; -; mRNA EMBL; AK022767; BAG51111.1; -; mRNA EMBL; AC004099; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; AC068400; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; AC068447; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; BC001172; AAH01172.1; -; mRNA EMBL; BC011753; AAH11753.1; -; mRNA EMBL; AF069732; AAC39902.1; -; mRNA CCDS; CCDS11319.1; -. [O75478-1] CCDS; CCDS45656.1; -. [O75478-2] RefSeq; NP_001159577.2; NM_001166105.2 RefSeq; NP_001278847.1; NM_001291918.1 RefSeq; NP_001479.4; NM_001488.4 RefSeq; NP_597683.3; NM_133439.3 UniGene; Hs.500066; - UniGene; Hs.633101; - PDB; 1X41; NMR; -; A=72-116 PDBsum; 1X41; - ProteinModelPortal; O75478; - SMR; O75478; - BioGrid; 112734; 154 ComplexPortal; CPX-1004; PCAF-containing ATAC complex ComplexPortal; CPX-989; PCAF histone acetylase complex ComplexPortal; CPX-997; GCN5-containing ATAC complex CORUM; O75478; - DIP; DIP-28151N; - IntAct; O75478; 51 MINT; O75478; - STRING; 9606.ENSP00000225396; - iPTMnet; O75478; - PhosphoSitePlus; O75478; - BioMuta; TADA2A; - EPD; O75478; - MaxQB; O75478; - PaxDb; O75478; - PeptideAtlas; O75478; - PRIDE; O75478; - ProteomicsDB; 50040; - ProteomicsDB; 50041; -. [O75478-2] DNASU; 6871; - Ensembl; ENST00000617828; ENSP00000482484; ENSG00000277104. [O75478-1] Ensembl; ENST00000622522; ENSP00000481283; ENSG00000277104. [O75478-1] Ensembl; ENST00000633468; ENSP00000488016; ENSG00000277104. [O75478-1] Ensembl; ENST00000633584; ENSP00000487973; ENSG00000277104. [O75478-2] GeneID; 6871; - KEGG; hsa:6871; - UCSC; uc032ghw.2; human. [O75478-1] CTD; 6871; - DisGeNET; 6871; - GeneCards; TADA2A; - H-InvDB; HIX0013744; - HGNC; HGNC:11531; TADA2A HPA; HPA076497; - MIM; 602276; gene neXtProt; NX_O75478; - PharmGKB; PA36306; - eggNOG; KOG0457; Eukaryota eggNOG; COG5114; LUCA HOGENOM; HOG000068147; - HOVERGEN; HBG057413; - InParanoid; O75478; - KO; K11314; - OrthoDB; EOG091G06WT; - PhylomeDB; O75478; - TreeFam; TF313975; - Reactome; R-HSA-3214847; HATs acetylate histones ChiTaRS; TADA2A; human EvolutionaryTrace; O75478; - GeneWiki; TADA2L; - GenomeRNAi; 6871; - PRO; PR:O75478; - Proteomes; UP000005640; Chromosome 17 CleanEx; HS_TADA2L; - GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell GO; GO:0005634; C:nucleus; TAS:ProtInc GO; GO:0000125; C:PCAF complex; IDA:UniProtKB GO; GO:0003682; F:chromatin binding; IBA:GO_Central GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW GO; GO:0003700; F:DNA binding transcription factor activity; TAS:ProtInc GO; GO:0000981; F:RNA polymerase II transcription factor activity, sequence-specific DNA binding; ISA:NTNU_SB GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central GO; GO:0003712; F:transcription coregulator activity; TAS:ProtInc GO; GO:0006338; P:chromatin remodeling; IBA:GO_Central GO; GO:0043966; P:histone H3 acetylation; IDA:UniProtKB GO; GO:0035066; P:positive regulation of histone acetylation; IBA:GO_Central GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central GO; GO:0006366; P:transcription by RNA polymerase II; TAS:ProtInc CDD; cd00167; SANT; 1 InterPro; IPR016827; Ada2/TADA2 InterPro; IPR009057; Homeobox-like_sf InterPro; IPR001005; SANT/Myb InterPro; IPR017884; SANT_dom InterPro; IPR007526; SWIRM Pfam; PF00249; Myb_DNA-binding; 1 Pfam; PF04433; SWIRM; 1 PIRSF; PIRSF025024; Transcriptional_adaptor_2; 1 SMART; SM00717; SANT; 1 SUPFAM; SSF46689; SSF46689; 2 PROSITE; PS51293; SANT; 1 PROSITE; PS50934; SWIRM; 1 1: Evidence at protein level; 3D-structure; Alternative splicing; Chromosome; Complete proteome; DNA-binding; Isopeptide bond; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transcription; Transcription regulation; Ubl conjugation CHAIN 1 443 Transcriptional adapter 2-alpha /FTId=PRO_0000197083 DOMAIN 70 122 SANT. {ECO:0000255|PROSITE- ProRule:PRU00624} DOMAIN 356 443 SWIRM. {ECO:0000255|PROSITE- ProRule:PRU00247} DNA_BIND 426 435 COMPBIAS 17 45 Cys-rich MOD_RES 6 6 Phosphoserine; in variant Ser-6 CROSSLNK 132 132 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) CROSSLNK 138 138 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) VAR_SEQ 275 305 LEFELRREIKRLQEYRTAGITNFCSARTYDH -> CRWFLS LEQYLCVYIYINRRDNGVFYVKFYK (in isoform 2) /FTId=VSP_040347 VAR_SEQ 306 443 Missing (in isoform 2) /FTId=VSP_040348 VARIANT 6 6 P -> S (in dbSNP:rs7211875) {ECO:0000244|PubMed:23186163, ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:8552087, ECO:0000269|Ref.2} /FTId=VAR_047466 VARIANT 115 115 M -> V (in dbSNP:rs1054865) /FTId=VAR_047467 VARIANT 351 351 I -> M (in dbSNP:rs2522969) /FTId=VAR_047468 CONFLICT 117 117 H -> Y (in Ref. 5; AAH01172) CONFLICT 153 153 P -> L (in Ref. 6; AAC39902) CONFLICT 185 185 W -> R (in Ref. 2; AAC26659) CONFLICT 304 304 D -> N (in Ref. 2; AAC26659) CONFLICT 342 342 D -> G (in Ref. 2; AAC26659) STRAND 73 75 {ECO:0000244|PDB:1X41} HELIX 77 89 {ECO:0000244|PDB:1X41} HELIX 95 102 {ECO:0000244|PDB:1X41} HELIX 107 117 {ECO:0000244|PDB:1X41} SEQUENCE 443 AA; 51506 MW; A4E1D87B1B3F6BA5 CRC64; MDRLGPFSND PSDKPPCRGC SSYLMEPYIK CAECGPPPFF LCLQCFTRGF EYKKHQSDHT YEIMTSDFPV LDPSWTAQEE MALLEAVMDC GFGNWQDVAN QMCTKTKEEC EKHYMKHFIN NPLFASTLLN LKQAEEAKTA DTAIPFHSTD DPPRPTFDSL LSRDMAGYMP ARADFIEEFD NYAEWDLRDI DFVEDDSDIL HALKMAVVDI YHSRLKERQR RKKIIRDHGL INLRKFQLME RRYPKEVQDL YETMRRFARI VGPVEHDKFI ESHALEFELR REIKRLQEYR TAGITNFCSA RTYDHLKKTR EEERLKRTML SEVLQYIQDS SACQQWLRRQ ADIDSGLSPS IPMASNSGRR SAPPLNLTGL PGTEKLNEKE KELCQMVRLV PGAYLEYKSA LLNECNKQGG LRLAQARALI KIDVNKTRKI YDFLIREGYI TKG
Research Areas
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Background

Many DNA-binding transcriptional activator proteinsenhance the initiation rate of RNA polymerase II-mediated genetranscription by interacting functionally with the generaltranscription machinery bound at the basal promoter. Adaptorproteins are usually required for this activation, possibly toacetylate and destabilize nucleosomes, thereby relieving chromatinconstraints at the promoter. The protein encoded by this gene is atranscriptional activator adaptor and has been found to be part ofthe PCAF histone acetylase complex. Several alternatively splicedtranscript variants encoding different isoforms of this gene havebeen described, but the full-length nature of some of thesevariants has not been determined.

References

Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)Yang, M., et al. Cancer Biol. Ther. 7(1):120-128(2008)Lamesch, P., et al. Genomics 89(3):307-315(2007)Qian, C., et al. Nat. Struct. Mol. Biol. 12(12):1078-1085(2005)Barlev, N.A., et al. Mol. Cell. Biol. 23(19):6944-6957(2003)

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