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TADA2L Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O75478 |
|---|---|
| Clone Names | 100528096 |
| Gene ID | 6871 |
|---|---|
| Other Names | Transcriptional adapter 2-alpha, Transcriptional adapter 2-like, ADA2-like protein, TADA2A, TADA2L |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TADA2A |
|---|---|
| Synonyms | TADA2L |
| Function | Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double- stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity (PubMed:22644376). May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage (PubMed:22644376). |
| Cellular Location | Nucleus. Chromosome {ECO:0000250|UniProtKB:Q8CHV6} |
| Tissue Location | Expressed in all tissues, but most abundantly in testis |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Many DNA-binding transcriptional activator proteinsenhance the initiation rate of RNA polymerase II-mediated genetranscription by interacting functionally with the generaltranscription machinery bound at the basal promoter. Adaptorproteins are usually required for this activation, possibly toacetylate and destabilize nucleosomes, thereby relieving chromatinconstraints at the promoter. The protein encoded by this gene is atranscriptional activator adaptor and has been found to be part ofthe PCAF histone acetylase complex. Several alternatively splicedtranscript variants encoding different isoforms of this gene havebeen described, but the full-length nature of some of thesevariants has not been determined.
References
Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)Yang, M., et al. Cancer Biol. Ther. 7(1):120-128(2008)Lamesch, P., et al. Genomics 89(3):307-315(2007)Qian, C., et al. Nat. Struct. Mol. Biol. 12(12):1078-1085(2005)Barlev, N.A., et al. Mol. Cell. Biol. 23(19):6944-6957(2003)
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