|Other Names||Transcriptional adapter 2-alpha, Transcriptional adapter 2-like, ADA2-like protein, TADA2A, TADA2L|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double- stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling.|
|Cellular Location||Nucleus. Chromosome.|
|Tissue Location||Expressed in all tissues, but most abundantly in testis|
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Provided below are standard protocols that you may find useful for product applications.
Many DNA-binding transcriptional activator proteinsenhance the initiation rate of RNA polymerase II-mediated genetranscription by interacting functionally with the generaltranscription machinery bound at the basal promoter. Adaptorproteins are usually required for this activation, possibly toacetylate and destabilize nucleosomes, thereby relieving chromatinconstraints at the promoter. The protein encoded by this gene is atranscriptional activator adaptor and has been found to be part ofthe PCAF histone acetylase complex. Several alternatively splicedtranscript variants encoding different isoforms of this gene havebeen described, but the full-length nature of some of thesevariants has not been determined.
Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)Yang, M., et al. Cancer Biol. Ther. 7(1):120-128(2008)Lamesch, P., et al. Genomics 89(3):307-315(2007)Qian, C., et al. Nat. Struct. Mol. Biol. 12(12):1078-1085(2005)Barlev, N.A., et al. Mol. Cell. Biol. 23(19):6944-6957(2003)
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