|Other Names||Indian hedgehog protein, IHH, HHG-2, Indian hedgehog protein N-product, Indian hedgehog protein C-product, IHH|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity).|
|Cellular Location||Indian hedgehog protein N-product: Cell membrane; Lipid-anchor; Extracellular side. Note=The N-terminal peptide remains associated with the cell surface. Cell membrane.|
|Tissue Location||Expressed in embryonic lung, and in adult kidney and liver|
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This gene encodes a member of the hedgehog family ofsecreted signaling molecules. Hedgehog proteins are essentialregulators of a variety of developmental processes includinggrowth, patterning and morphogenesis. The encoded proteinspecifically plays a role in bone growth an differentiation.Mutations in this gene are the cause of brachydactyly type A1 whichis characterized by shortening or malformation of the phalanges.Mutations in this gene are also the cause of acrocapitofemoraldysplasia.
Meulenbelt, I., et al. Ann. Rheum. Dis. (2010) In press :Kang, S.J., et al. Hum. Mol. Genet. 19(13):2725-2738(2010)Okada, Y., et al. Hum. Mol. Genet. 19(11):2303-2312(2010)Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :Chuang, P.T., et al. Nature 397(6720):617-621(1999)
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