|Other Names||Nucleoside diphosphate kinase A, NDK A, NDP kinase A, Granzyme A-activated DNase, GAAD, Metastasis inhibition factor nm23, NM23-H1, Tumor metastatic process-associated protein, NME1, NDPKA, NM23|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein- coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair.|
|Cellular Location||Cytoplasm. Nucleus. Note=Cell-cycle dependent nuclear localization which can be induced by interaction with Epstein-barr viral proteins or by degradation of the SET complex by GzmA|
|Tissue Location||Isoform 1 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen and thymus. Expressed in lung carcinoma cell lines but not in normal lung tissues. Isoform 2 is ubiquitously expressed and its expression is also related to tumor differentiation|
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This gene (NME1) was identified because of its reducedmRNA transcript levels in highly metastatic cells. Nucleosidediphosphate kinase (NDK) exists as a hexamer composed of 'A'(encoded by this gene) and 'B' (encoded by NME2) isoforms.Mutations in this gene have been identified in aggressiveneuroblastomas. Two transcript variants encoding different isoformshave been found for this gene. Co-transcription of this gene andthe neighboring downstream gene (NME2) generatesnaturally-occurring transcripts (NME1-NME2), which encodes a fusionprotein comprised of sequence sharing identity with each individualgene product.
Boissan, M., et al. Cancer Res. 70(19):7710-7722(2010)Wang, P.H., et al. Gynecol. Oncol. 119(1):70-75(2010)Conery, A.R., et al. Proc. Natl. Acad. Sci. U.S.A. 107(35):15461-15466(2010)Wang, Z., et al. Med. Sci. Monit. 16 (8), CR357-CR364 (2010) :Li, Y., et al. Cancer Res. 70(14):5695-5705(2010)
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