|Other Names||Activin receptor type-2A, Activin receptor type IIA, ACTR-IIA, Acvr2a, Acvr2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Brain, testis, intestine, liver and kidney.|
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Provided below are standard protocols that you may find useful for product applications.
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.
Perron, J.C., et al. PLoS ONE 4 (12), E8198 (2009) :Morita, S., et al. PLoS ONE 4 (1), E4212 (2009) :Kamiya, N., et al. Development 135(22):3801-3811(2008)Xia, Y., et al. J. Biol. Chem. 282(25):18129-18140(2007)Lee, Y.J., et al. Genesis 44(10):487-494(2006)
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