|Other Names||Azurocidin, Cationic antimicrobial protein CAP37, Heparin-binding protein, HBP, AZU1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram- negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has antibacterial activity against C.sputigena ATCC 33123 when acting synergistically with either elastase or cathepsin G.|
|Cellular Location||Cytoplasmic granule membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to azurophil granules of neutrophil granulocytes. Also called primary granules, these specialized lysosomes of the neutrophil formed early during promyelocyte development store antibacterial proteins and peptides.|
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Azurophil granules, specialized lysosomes of theneutrophil, contain at least 10 proteins implicated in the killingof microorganisms. The protein encoded by this gene is an azurophilgranule antibiotic protein, with monocyte chemotactic andantibacterial activity. It is also an important multifunctionalinflammatory mediator. This encoded protein is a member of theserine protease gene family but it is not a serine proteinase,because the active site serine and histidine residues are replaced.The genes encoding this protein, neutrophil elastase 2, andproteinase 3 are in a cluster located at chromosome 19pter. All 3genes are expressed coordinately and their protein products arepackaged together into azurophil granules during neutrophildifferentiation.
Changho, S., et al. Pathol. Res. Pract. 206(5):314-317(2010)Linder, A., et al. J. Invest. Dermatol. 130(5):1365-1372(2010)Segat, L., et al. Vaccine 28(10):2201-2206(2010)Wilker, E., et al. Environ. Health Perspect. 117(6):935-940(2009)Di Gennaro, A., et al. FASEB J. 23(6):1750-1757(2009)
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