|Other Names||StAR-related lipid transfer protein 3, Metastatic lymph node gene 64 protein, MLN 64, Protein CAB1, START domain-containing protein 3, StARD3, STARD3, CAB1, MLN64|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed:11053434, PubMed:15930133, PubMed:22514632, PubMed:28377464). Creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (PubMed:24105263, PubMed:28377464). Acts as a lipid transfer protein that redirects sterol to the endosome at the expense of the cell membrane and favors membrane formation inside endosomes (PubMed:28377464). May also mediate cholesterol transport between other membranes, such as mitochondria membrane or cell membrane (PubMed:12070139, PubMed:19965586). However, such results need additional experimental evidences; probably mainly mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed:28377464). Does not activate transcriptional cholesterol sensing (PubMed:28377464). Able to bind other lipids, such as lutein, a xanthophyll carotenoids that form the macular pigment of the retina (PubMed:21322544).|
|Cellular Location||Late endosome membrane; Multi- pass membrane protein. Note=Localizes to contact sites between the endoplasmic reticulum and late endosomes: associates with the endoplasmic reticulum membrane via interaction with VAPA and VAPB (PubMed:24105263)|
|Tissue Location||Expressed in retina.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of a subfamily of lipidtrafficking proteins that are characterized by a C-terminalsteroidogenic acute regulatory domain and an N-terminal metastaticlymph node 64 domain. The encoded protein localizes to themembranes of late endosomes and may be involved in exportingcholesterol. Alternative splicing results in multiple transcriptvariants.
Bailey, S.D., et al. Diabetes Care (2010) In press :Charman, M., et al. J. Lipid Res. 51(5):1023-1034(2010)Cai, W., et al. Int. J. Mol. Med. 25(4):573-580(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Alpy, F., et al. J. Biol. Chem. 276(6):4261-4269(2001)
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