|Other Names||Proton-coupled folate transporter, G21, Heme carrier protein 1, PCFT/HCP1, Solute carrier family 46 member 1, SLC46A1, HCP1, PCFT|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Has been shown to act both as an intestinal proton- coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme.|
|Cellular Location||Apical cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Localizes to the apical membrane of intestinal cells in iron-deficient cells, while it resides in the cytoplasm in iron-replete cells.|
|Tissue Location||Expressed in kidney, liver, placenta, small intestine, spleen, retina and retinal pigment epithelium. Lower levels found in colon and testis. Very low levels in brain, lung, stomach, heart and muscle. In intestine, expressed in duodenum with lower levels in jejunum, ileum, cecum, rectum and segments of the colon.|
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This gene encodes a transmembrane proton-coupled folatetransporter protein that facilitates the movement of folate andantifolate substrates across cell membranes optimally in acidic pHenvironments. This protein is also expressed in the brain andchoroid plexus where it transports folates into the central nervoussystem. This protein further functions as a transmembrane hemetransporter in duodenal enterocytes and, potentially, in othertissues like liver and kidney. Its localization to the apicalmembrane or cytoplasm of intestinal cells is modulated by dietaryiron levels. Mutations in this gene cause the autosomal recessivehereditary folate malabsorption (HFM) disease. HFM is characterizedby folate deficiency due to reduced intestinal folate absorptionand subsequent anemia, hypoimmunoglobulinemia, and recurrentinfections.
Mahadeo, K., et al. Am. J. Physiol., Cell Physiol. 299 (5), C1153-C1161 (2010) :Gonen, N., et al. J. Biol. Chem. 285(44):33602-33613(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Zhao, R., et al. Biochemistry 49(13):2925-2931(2010)Solanky, N., et al. Placenta 31(2):134-143(2010)
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