|Other Names||Cadherin-3, Placental cadherin, P-cadherin, CDH3, CDHP|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1499a was selected from the C-term region of human CDH3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in some normal epithelial tissues and in some carcinoma cell lines.|
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Provided below are standard protocols that you may find useful for product applications.
CDH3 is a classical cadherin from the cadherin superfamily. It is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in the gene encoding CDH3 have been associated with congential hypotrichosis with juvenile macular dystrophy.
Indelman,M., Clin. Exp. Dermatol. 32 (2), 191-196 (2007)Paredes,J., Clin. Cancer Res. 11 (16), 5869-5877 (2005)
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