|Other Names||Gap junction beta-1 protein, Connexin-32, Cx32, GAP junction 28 kDa liver protein, GJB1, CX32|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1551b was selected from the C-term region of human GJB1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cell junction, gap junction|
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Gap junctions are conduits that allow the direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular metabolic and electrical communication. Gap junction channels consist of connexin protein subunits, which are encoded by a multigene family. GJBs (gap-junction proteins or connexins) play crucial functional roles associated with these channels.GJB1 is normally found in the paranodal myelin loops and Schmidt-Lanterman incisures of myelinating Schwann cells in the peripheral nervous system, as well as in oligodendrocytes and their processes, but not in compact myelin of the central nervous system. A series of mutational and other studies have directly linked defects in GJB1 to X-linked Charcot-Marie-Tooth disease (CMTX), a clinically and genetically heterogeneous group of hereditary motor and sensory peripheral neuropathies.
Dagli, M.L., et al., Carcinogenesis 25(4):483-492 (2004).Wang, H.L., et al., Neurobiol. Dis. 15(2):361-370 (2004).Kochanski, A., et al., J. Appl. Genet. 45(1):95-100 (2004).Gomez-Hernandez, J.M., et al., Proc. Natl. Acad. Sci. U.S.A. 100(26):16030-16035 (2003).Yang, J., et al., Biochem. Biophys. Res. Commun. 307(1):80-85 (2003).
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