|Other Names||Neuron-specific calcium-binding protein hippocalcin, Calcium-binding protein BDR-2, HPCA, BDR2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1564c was selected from the Center region of human Hippocalcin . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds two calcium ions.|
|Tissue Location||Brain specific..|
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Provided below are standard protocols that you may find useful for product applications.
Hippocalcin is a member of neuron-specific calcium-binding proteins family found in the retina and brain. This protein is associated with the plasma membrane. It has similarities to proteins located in the photoreceptor cells that regulate photosignal transduction in a calcium-sensitive manner. This protein displays recoverin activity and a calcium-dependent inhibition of rhodopsin kinase. It is identical to the rat and mouse hippocalcin proteins and thought to play an important role in neurons of the central nervous system in a number of species.
Takamatsu, K., et al., Biochem. Biophys. Res. Commun. 200(1):606-611 (1994).Hidaka, H., et al., Neurosci. Res. 16(2):73-77 (1993).Kobayashi, M., et al., Biochem. Biophys. Res. Commun. 189(1):511-517 (1992).Masaki, T., et al., Gene 225 (1-2), 117-124 (1998).Ivings, L., et al., Biochem. J. 363 (Pt 3), 599-608 (2002).
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