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KChIP1 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9NZI2 |
|---|---|
| Clone Names | 2010407 |
| Gene ID | 30820 |
|---|---|
| Other Names | Kv channel-interacting protein 1, KChIP1, A-type potassium channel modulatory protein 1, Potassium channel-interacting protein 1, Vesicle APC-binding protein, KCNIP1, KCHIP1, VABP |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP1571a was selected from the N-term region of human KChIP1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | KCNIP1 |
|---|---|
| Synonyms | KCHIP1, VABP |
| Function | Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Regulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents. Increases the presence of KCND2 at the cell surface. |
| Cellular Location | Cell membrane; Peripheral membrane protein. Cytoplasm. Cell projection, dendrite {ECO:0000250|UniProtKB:Q8R426} |
| Tissue Location | Isoform 1 and isoform 2 are expressed in brain and kidney. Isoform 1 is also expressed in liver, pancreas, skeletal muscle, small intestine and testis. Isoform 2 is also expressed in lung, pancreas, leukocytes, prostate and thymus |
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Provided below are standard protocols that you may find useful for product applications.
Background
KChIP1 is a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium.
References
Bahring, R., et al., J. Biol. Chem. 276(26):23888-23894 (2001).An, W.F., et al., Nature 403(6769):553-556 (2000).
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