|Other Names||Folate receptor beta, FR-beta, Folate receptor 2, Folate receptor, fetal/placental, Placental folate-binding protein, FBP, FOLR2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor. Secreted|
|Tissue Location||Expressed in placenta and hematopoietic cells. Expression is increased in malignant tissues|
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The protein encoded by this gene is a member of the folatereceptor (FOLR) family, and these genes exist in a cluster onchromosome 11. Members of this gene family have a high affinity forfolic acid and for several reduced folic acid derivatives, and theymediate delivery of 5-methyltetrahydrofolate to the interior ofcells. This protein has a 68% and 79% sequence homology with theFOLR1 and FOLR3 proteins, respectively. Although this protein wasoriginally thought to be specific to placenta, it can also exist inother tissues, and it may play a role in the transport ofmethotrexate in synovial macrophages in rheumatoid arthritispatients. Multiple transcript variants that encode the same proteinhave been found for this gene.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)O'Byrne, M.R., et al. Birth Defects Res. Part A Clin. Mol. Teratol. 88(8):689-694(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :Puig-Kroger, A., et al. Cancer Res. 69(24):9395-9403(2009)
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