|Other Names||Tumor necrosis factor receptor superfamily member 3, Lymphotoxin-beta receptor, Tumor necrosis factor C receptor, Tumor necrosis factor receptor 2-related protein, Tumor necrosis factor receptor type III, TNF-RIII, TNFR-III, LTBR, D12S370, TNFCR, TNFR3, TNFRSF3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||D12S370, TNFCR, TNFR3, TNFRSF3|
|Function||Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the tumornecrosis factor (TNF) family of receptors. It is expressed on thesurface of most cell types, including cells of epithelial andmyeloid lineages, but not on T and B lymphocytes. The proteinspecifically binds the lymphotoxin membrane form (a complex oflymphotoxin-alpha and lymphtoxin-beta). The encoded protein and itsligand play a role in the development and organization of lymphoidtissue and tranformed cells. Activation of the encoded protein cantrigger apoptosis.
Cheung, T.C., et al. J. Immunol. 185(3):1949-1958(2010)Han, S., et al. Hum. Immunol. 71(7):727-730(2010)Sanjo, H., et al. J. Biol. Chem. 285(22):17148-17155(2010)Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1356-1361(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)
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