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LTBR Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P36941 |
|---|---|
| Clone Names | 100507270 |
| Gene ID | 4055 |
|---|---|
| Other Names | Tumor necrosis factor receptor superfamily member 3, Lymphotoxin-beta receptor, Tumor necrosis factor C receptor, Tumor necrosis factor receptor 2-related protein, Tumor necrosis factor receptor type III, TNF-RIII, TNFR-III, LTBR, D12S370, TNFCR, TNFR3, TNFRSF3 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | LTBR |
|---|---|
| Synonyms | D12S370, TNFCR, TNFR3, TNFRSF3 |
| Function | Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs. |
| Cellular Location | Membrane; Single-pass type I membrane protein. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of the tumornecrosis factor (TNF) family of receptors. It is expressed on thesurface of most cell types, including cells of epithelial andmyeloid lineages, but not on T and B lymphocytes. The proteinspecifically binds the lymphotoxin membrane form (a complex oflymphotoxin-alpha and lymphtoxin-beta). The encoded protein and itsligand play a role in the development and organization of lymphoidtissue and tranformed cells. Activation of the encoded protein cantrigger apoptosis.
References
Cheung, T.C., et al. J. Immunol. 185(3):1949-1958(2010)Han, S., et al. Hum. Immunol. 71(7):727-730(2010)Sanjo, H., et al. J. Biol. Chem. 285(22):17148-17155(2010)Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1356-1361(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)
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