|Other Names||Small glutamine-rich tetratricopeptide repeat-containing protein alpha, Alpha-SGT, Vpu-binding protein, UBP, SGTA, SGT, SGT1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails (PubMed:28104892). Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module (PubMed:28104892). Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins (PubMed:28104892, PubMed:25535373). It is also involved in the regulation of the endoplasmic reticulum- associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states (PubMed:23129660, PubMed:25179605). Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex (PubMed:27193484). Binds directly to HSC70 and HSP70 and regulates their ATPase activity (PubMed:18759457).|
|Cellular Location||Cytoplasm. Nucleus. Note=Co-localizes with HSP90AB1 in the cytoplasm. Increased nuclear accumulation seen during cell apoptosis.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein which is capable ofinteracting with the major nonstructural protein of parvovirus H-1and 70-kDa heat shock cognate protein; however, its function is notknown. Since this transcript is expressed ubiquitously in varioustissues, this protein may serve a housekeeping function. [providedby RefSeq].
Ewens, K.G., et al. J. Clin. Endocrinol. Metab. 95(5):2306-2315(2010)Dutta, S., et al. Biochemistry 47(38):10123-10131(2008)Dutta, S., et al. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 64 (PT 7), 602-604 (2008) :Goodarzi, M.O., et al. Hum. Reprod. 23(5):1214-1219(2008)Buchanan, G., et al. Cancer Res. 67(20):10087-10096(2007)
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