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SGTA Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O43765 |
|---|---|
| Clone Names | 100525221 |
| Gene ID | 6449 |
|---|---|
| Other Names | Small glutamine-rich tetratricopeptide repeat-containing protein alpha, Alpha-SGT, Vpu-binding protein, UBP, SGTA, SGT, SGT1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SGTA |
|---|---|
| Synonyms | SGT, SGT1 |
| Function | Co-chaperone that binds misfolded and hydrophobic patches- containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails (PubMed:28104892). Functions in tail- anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module (PubMed:28104892). Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins (PubMed:28104892, PubMed:25535373). It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states (PubMed:23129660, PubMed:25179605). Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex (PubMed:27193484). Binds directly to HSC70 and HSP70 and regulates their ATPase activity (PubMed:18759457). |
| Cellular Location | Cytoplasm. Nucleus. Note=Co-localizes with HSP90AB1 in the cytoplasm. Increased nuclear accumulation seen during cell apoptosis |
| Tissue Location | Ubiquitous. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein which is capable ofinteracting with the major nonstructural protein of parvovirus H-1and 70-kDa heat shock cognate protein; however, its function is notknown. Since this transcript is expressed ubiquitously in varioustissues, this protein may serve a housekeeping function. [providedby RefSeq].
References
Ewens, K.G., et al. J. Clin. Endocrinol. Metab. 95(5):2306-2315(2010)Dutta, S., et al. Biochemistry 47(38):10123-10131(2008)Dutta, S., et al. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 64 (PT 7), 602-604 (2008) :Goodarzi, M.O., et al. Hum. Reprod. 23(5):1214-1219(2008)Buchanan, G., et al. Cancer Res. 67(20):10087-10096(2007)
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