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SORD Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q00796 |
|---|---|
| Clone Names | 100528025 |
| Gene ID | 6652 |
|---|---|
| Other Names | Sorbitol dehydrogenase, L-iditol 2-dehydrogenase, SORD |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SORD |
|---|---|
| Function | Polyol dehydrogenase that catalyzes the reversible NAD(+)- dependent oxidation of various sugar alcohols. Is mostly active with D- sorbitol (D-glucitol), L-threitol, xylitol and ribitol as substrates, leading to the C2-oxidized products D-fructose, L-erythrulose, D- xylulose, and D-ribulose, respectively (PubMed:3365415). Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. The polyol pathway is believed to be involved in the etiology of diabetic complications, such as diabetic neuropathy and retinopathy, induced by hyperglycemia (PubMed:12962626, PubMed:29966615, PubMed:25105142). May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility (PubMed:16278369). May have a more general function in the metabolism of secondary alcohols since it also catalyzes the stereospecific oxidation of (2R,3R)-2,3-butanediol. To a lesser extent, can also oxidize L-arabinitol, galactitol and D-mannitol and glycerol in vitro. Oxidizes neither ethanol nor other primary alcohols. Cannot use NADP(+) as the electron acceptor (PubMed:3365415). |
| Cellular Location | Mitochondrion membrane {ECO:0000250|UniProtKB:Q64442}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q64442}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q64442}. Note=Associated with mitochondria of the midpiece and near the plasma membrane in the principal piece of the flagellum. Also found in the epididymosome, secreted by the epididymal epithelium and that transfers proteins from the epididymal fluid to the sperm surface. {ECO:0000250|UniProtKB:Q64442} |
| Tissue Location | Expressed in liver (PubMed:3365415). Expressed in kidney and epithelial cells of both benign and malignant prostate tissue. Expressed in epididymis (at protein level) |
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Provided below are standard protocols that you may find useful for product applications.
Background
Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes theinterconversion of polyols and their corresponding ketoses, andtogether with aldose reductase (ALDR1; MIM 103880), makes up thesorbitol pathway that is believed to play an important role in thedevelopment of diabetic complications (summarized by Carr andMarkham, 1995 [PubMed 8535074]). The first reaction of the pathway(also called the polyol pathway) is the reduction of glucose tosorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizesthe sorbitol to fructose using NAD(+) cofactor.
References
Szabo, Z., et al. Oncol. Rep. 23(5):1233-1239(2010)Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :El-Kabbani, O., et al. Curr. Med. Chem. 11(4):465-476(2004)Pauly, T.A., et al. Structure 11(9):1071-1085(2003)Darmanin, C., et al. Acta Crystallogr. D Biol. Crystallogr. 59 (PT 3), 558-560 (2003) :
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