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SORD Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q00796
Clone Names 100528025
Peptide ID 100528025
Additional Information
Gene ID 6652
Other Names Sorbitol dehydrogenase, L-iditol 2-dehydrogenase, SORD
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Function Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm.
Cellular Location Mitochondrion membrane {ECO:0000250|UniProtKB:Q64442}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q64442}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q64442}. Note=Associated with mitochondria of the midpiece and near the plasma membrane in the principal piece of the flagellum. Also found in the epididymosome, secreted by the epididymal epithelium and that transfers proteins from the epididymal fluid to the sperm surface {ECO:0000250|UniProtKB:Q64442}
Tissue Location Expressed in kidney and epithelial cells of both benign and malignant prostate tissue. Expressed in epididymis (at protein level).
Research Areas
Citations (0)

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Sorbitol dehydrogenase (SORD; EC catalyzes theinterconversion of polyols and their corresponding ketoses, andtogether with aldose reductase (ALDR1; MIM 103880), makes up thesorbitol pathway that is believed to play an important role in thedevelopment of diabetic complications (summarized by Carr andMarkham, 1995 [PubMed 8535074]). The first reaction of the pathway(also called the polyol pathway) is the reduction of glucose tosorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizesthe sorbitol to fructose using NAD(+) cofactor.


Szabo, Z., et al. Oncol. Rep. 23(5):1233-1239(2010)Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :El-Kabbani, O., et al. Curr. Med. Chem. 11(4):465-476(2004)Pauly, T.A., et al. Structure 11(9):1071-1085(2003)Darmanin, C., et al. Acta Crystallogr. D Biol. Crystallogr. 59 (PT 3), 558-560 (2003) :

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$ 80.00
Cat# BP16049c
(40 western blots)
Availability: In Stock
Bulk Size
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