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TRAF4 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9BUZ4 |
|---|---|
| Clone Names | 100528053 |
| Gene ID | 9618 |
|---|---|
| Other Names | TNF receptor-associated factor 4, Cysteine-rich domain associated with RING and Traf domains protein 1, Metastatic lymph node gene 62 protein, MLN 62, RING finger protein 83, TRAF4, CART1, MLN62, RNF83 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TRAF4 |
|---|---|
| Synonyms | CART1, MLN62, RNF83 |
| Function | Adapter protein with E3 ligase activity that is involved in many diverse biological processes including cell proliferation, migration, differentiation, DNA repair, platelet activation or apoptosis (PubMed:30352854, PubMed:31076633, PubMed:32268273, PubMed:33991522). Promotes EGFR-mediated signaling by facilitating the dimerization of EGFR and downstream AKT activation thereby promoting cell proliferation (PubMed:30352854). Ubiquitinates SMURF2 through 'Lys-48'-linked ubiquitin chain leading to SMURF2 degradation through the proteasome and subsequently osteogenic differentiation (PubMed:31076633). Promotes 'Lys-63'-mediated ubiquitination of CHK1 which in turn activates cell cycle arrest and activation of DNA repair (PubMed:32357935). In addition, promotes an atypical 'Lys-29'-linked ubiquitination at the C-terminal end of IRS1 which is crucial for insulin-like growth factor (IGF) signal transduction (PubMed:33991522). Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions. Inhibits adipogenic differentiation by activating pyruvate kinase PKM activity and subsequently the beta-catenin signaling pathway (PubMed:32268273). |
| Cellular Location | Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Cell junction, tight junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton |
| Tissue Location | Expressed in epithelial cells of thymus, dendritic cells of lymph node, and in the basal cell layer of epithelia such as epidermis, nasopharynx, respiratory tract, salivary gland, and esophagus. |
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Background
This gene encodes a member of the TNF receptor associatedfactor (TRAF) family. TRAF proteins are associated with, andmediate signal transduction from members of the TNF receptorsuperfamily. The encoded protein has been shown to interact withneurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTRinduced cell death and NF-kappa B activation. This protein has beenfound to bind to p47phox, a cytosolic regulatory factor included ina multi-protein complex known as NAD(P)H oxidase. This proteinthus, is thought to be involved in the oxidative activation ofMAPK8/JNK. Alternatively spliced transcript variants have beenobserved but the full-length nature of only one has beendetermined.
References
Li, S., et al. Mol. Cell. Biochem. 338 (1-2), 11-17 (2010) :Davila, S., et al. Genes Immun. 11(3):232-238(2010)Segat, L., et al. Vaccine 28(10):2201-2206(2010)Albers, H.M., et al. Ann. Rheum. Dis. 67(11):1578-1580(2008)Kedinger, V., et al. PLoS ONE 3 (10), E3518 (2008) :
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