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TRPM4 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q8TD43
Clone Names 100528057
Peptide ID 100528057
Additional Information
Gene ID 54795
Other Names Transient receptor potential cation channel subfamily M member 4, hTRPM4, Calcium-activated non-selective cation channel 1, Long transient receptor potential channel 4, LTrpC-4, LTrpC4, Melastatin-4, TRPM4, LTRPC4
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRPM4
Synonyms LTRPC4
Function Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway.
Cellular Location Isoform 1: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum. Golgi apparatus
Tissue Location Widely expressed with a high expression in intestine and prostate. In brain, it is both expressed in whole cerebral arteries and isolated vascular smooth muscle cells Prominently expressed in Purkinje fibers. Expressed at higher levels in T-helper 2 (Th2) cells as compared to T-helper 1 (Th1) cells.
Research Areas
Citations (0)

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The protein encoded by this gene is a calcium-activatednonselective ion channel that mediates transport of monovalentcations across membranes, thereby depolarizing the membrane. Theactivity of the encoded protein increases with increasingintracellular calcium concentration, but this channel does nottransport calcium. Two transcript variants encoding differentisoforms have been found for this gene.


Liu, H., et al. Circ Cardiovasc Genet 3(4):374-385(2010)Yoo, J.C., et al. Biochem. Biophys. Res. Commun. 391(1):806-811(2010)Kruse, M., et al. J. Clin. Invest. 119(9):2737-2744(2009)Marigo, V., et al. Mol. Cell. Endocrinol. 299(2):194-203(2009)Park, J.Y., et al. Biochem. Biophys. Res. Commun. 368(3):677-683(2008)

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$ 80.00
Cat# BP16061b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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