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TRPM4 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8TD43 |
|---|---|
| Clone Names | 100528057 |
| Gene ID | 54795 |
|---|---|
| Other Names | Transient receptor potential cation channel subfamily M member 4, hTRPM4, Calcium-activated non-selective cation channel 1, Long transient receptor potential channel 4, LTrpC-4, LTrpC4, Melastatin-4, TRPM4, LTRPC4 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TRPM4 (HGNC:17993) |
|---|---|
| Synonyms | LTRPC4 |
| Function | Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization (PubMed:12015988, PubMed:29211723, PubMed:30528822). While it is activated by increase in intracellular Ca(2+), it is impermeable to it (PubMed:12015988). Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway. Plays a role in keratinocyte differentiation (PubMed:30528822). |
| Cellular Location | [Isoform 1]: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum. Golgi apparatus |
| Tissue Location | Widely expressed with a high expression in intestine and prostate. In brain, it is both expressed in whole cerebral arteries and isolated vascular smooth muscle cells Prominently expressed in Purkinje fibers. Expressed at higher levels in T-helper 2 (Th2) cells as compared to T-helper 1 (Th1) cells. Expressed in keratocytes (PubMed:30528822). |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a calcium-activatednonselective ion channel that mediates transport of monovalentcations across membranes, thereby depolarizing the membrane. Theactivity of the encoded protein increases with increasingintracellular calcium concentration, but this channel does nottransport calcium. Two transcript variants encoding differentisoforms have been found for this gene.
References
Liu, H., et al. Circ Cardiovasc Genet 3(4):374-385(2010)Yoo, J.C., et al. Biochem. Biophys. Res. Commun. 391(1):806-811(2010)Kruse, M., et al. J. Clin. Invest. 119(9):2737-2744(2009)Marigo, V., et al. Mol. Cell. Endocrinol. 299(2):194-203(2009)Park, J.Y., et al. Biochem. Biophys. Res. Commun. 368(3):677-683(2008)
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