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Mouse Mark4 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q8CIP4
Other Accession NP_758483.1
Clone Names 110316262
Peptide ID 110316262
Additional Information
Gene ID 232944
Other Names MAP/microtubule affinity-regulating kinase 4, Mark4, Kiaa1860
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Mark4
Synonyms Kiaa1860
Function Serine/threonine-protein kinase (By similarity). Phosphorylates the microtubule-associated protein MAPT/TAU (By similarity). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (By similarity). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (By similarity). Required for the initiation of axoneme extension during cilium assembly (By similarity). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (By similarity). Plays a role in cell cycle progression, specifically in the G1/S checkpoint (By similarity). Reduces neuronal cell survival (By similarity). Plays a role in energy homeostasis by regulating satiety and metabolic rate (PubMed:22992738). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (PubMed:24989893). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation (By similarity).
Cellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q96L34} Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000250|UniProtKB:Q96L34}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q96L34}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q96L34}. Cytoplasm {ECO:0000250|UniProtKB:Q96L34}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q96L34}. Note=Localized at the tips of neurite-like processes in differentiated neuroblast cells Detected in the cytoplasm and neuropil of the hippocampus {ECO:0000250|UniProtKB:Q96L34}
Tissue Location Isoform 1 and isoform 2 show similar expression patterns in the central nervous system and are present in the same subsets of neurons including pyramidal and non- pyramidal neurons in the cerebral cortex and hippocampus, cerebellar Purkinje cells, and interneurons and motor neurons in the spinal cord but not in glial cells (at protein level) (PubMed:16973293). Isoform 2 is the major isoform in brain and cerebellum (PubMed:16973293, PubMed:15009667). Also expressed in spleen, liver, small intestine, colon, kidney, tongue, testis and lung (PubMed:16973293, PubMed:15009667). Isoform 1 and isoform 2 are expressed at similar levels in heart (PubMed:16973293)
Research Areas
Citations (0)

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Schneider, A., et al. J. Neurochem. 88(5):1114-1126(2004)Zambrowicz, B.P., et al. Proc. Natl. Acad. Sci. U.S.A. 100(24):14109-14114(2003)Okazaki, N., et al. DNA Res. 10(1):35-48(2003)Stryke, D., et al. Nucleic Acids Res. 31(1):278-281(2003)Lee, Y.J., et al. FEBS Lett. 472 (2-3), 230-234 (2000) :

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$ 80.00
Cat# BP16077b
Availability: In Stock
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