|Other Names||Heterogeneous nuclear ribonucleoprotein D0, hnRNP D0, AU-rich element RNA-binding protein 1, HNRNPD, AUF1, HNRPD|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto- oncogenes and cytokine mRNAs. Also binds to double- and single- stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'- TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3'UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation.|
|Cellular Location||Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Component of ribonucleosomes. Cytoplasmic localization oscillates diurnally|
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This gene belongs to the subfamily of ubiquitouslyexpressed heterogeneous nuclear ribonucleoproteins (hnRNPs). ThehnRNPs are nucleic acid binding proteins and they complex withheterogeneous nuclear RNA (hnRNA). These proteins are associatedwith pre-mRNAs in the nucleus and appear to influence pre-mRNAprocessing and other aspects of mRNA metabolism and transport.While all of the hnRNPs are present in the nucleus, some seem toshuttle between the nucleus and the cytoplasm. The hnRNP proteinshave distinct nucleic acid binding properties. The protein encodedby this gene has two repeats of quasi-RRM domains that bind toRNAs. It localizes to both the nucleus and the cytoplasm. Thisprotein is implicated in the regulation of mRNA stability.Alternative splicing of this gene results in four transcriptvariants.
Ishimaru, D., et al. J. Biol. Chem. 285(35):27182-27191(2010)Zhai, B., et al. J. Biol. Chem. 285(31):23568-23580(2010)Vazquez-Chantada, M., et al. Gastroenterology 138(5):1943-1953(2010)Trojanowicz, B., et al. Endocr. Relat. Cancer 16(3):857-871(2009)Pautz, A., et al. J. Biol. Chem. 284(5):2755-2766(2009)
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