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SLC24A1 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O60721 |
|---|---|
| Clone Names | 100405065 |
| Gene ID | 9187 |
|---|---|
| Other Names | Sodium/potassium/calcium exchanger 1, Na(+)/K(+)/Ca(2+)-exchange protein 1, Retinal rod Na-Ca+K exchanger, Solute carrier family 24 member 1, SLC24A1, KIAA0702, NCKX1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SLC24A1 {ECO:0000303|PubMed:20850105, ECO:0000312|HGNC:HGNC:10975} |
|---|---|
| Function | Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) (PubMed:26631410). Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness (PubMed:20850105). Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation (PubMed:20850105). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in the retina, particularly in the inner segment, outer and inner nuclear layers, and ganglion cell layer |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
SLC24A1 belongs to a family of potassium-dependentsodium/calcium exchangers. Members of this family have 2 largehydrophilic loops and 2 sets of multiple transmembrane-spanningsegments (Schnetkamp, 2004 [PubMed 14770312]).
References
Riazuddin, S.A., et al. Am. J. Hum. Genet. 87(4):523-531(2010)Kamatani, Y., et al. Nat. Genet. 42(3):210-215(2010)Wu, C., et al. Proteomics 7(11):1775-1785(2007)Schnetkamp, P.P. Pflugers Arch. 447(5):683-688(2004)Kang, K., et al. Biochemistry 42(15):4593-4600(2003)
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