|Other Names||Sodium/potassium/calcium exchanger 1, Na(+)/K(+)/Ca(2+)-exchange protein 1, Retinal rod Na-Ca+K exchanger, Solute carrier family 24 member 1, SLC24A1, KIAA0702, NCKX1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+).|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed in the retina, particularly in the inner segment, outer and inner nuclear layers, and ganglion cell layer.|
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Provided below are standard protocols that you may find useful for product applications.
SLC24A1 belongs to a family of potassium-dependentsodium/calcium exchangers. Members of this family have 2 largehydrophilic loops and 2 sets of multiple transmembrane-spanningsegments (Schnetkamp, 2004 [PubMed 14770312]).
Riazuddin, S.A., et al. Am. J. Hum. Genet. 87(4):523-531(2010)Kamatani, Y., et al. Nat. Genet. 42(3):210-215(2010)Wu, C., et al. Proteomics 7(11):1775-1785(2007)Schnetkamp, P.P. Pflugers Arch. 447(5):683-688(2004)Kang, K., et al. Biochemistry 42(15):4593-4600(2003)
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