|Other Names||T-lymphocyte activation antigen CD86, Activation B7-2 antigen, B70, BU63, CTLA-4 counter-receptor B72, FUN-1, CD86, CD86, CD28LG2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T- cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed by activated B-lymphocytes and monocytes|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This gene encodes a type I membrane protein that is amember of the immunoglobulin superfamily. This protein is expressedby antigen-presenting cells, and it is the ligand for two proteinsat the cell surface of T cells, CD28 antigen and cytotoxicT-lymphocyte-associated protein 4. Binding of this protein withCD28 antigen is a costimulatory signal for activation of theT-cell. Binding of this protein with cytotoxicT-lymphocyte-associated protein 4 negatively regulates T-cellactivation and diminishes the immune response. Alternative splicingresults in two transcript variants encoding different isoforms.Additional transcript variants have been described, but theirfull-length sequences have not been determined. [provided byRefSeq].
Liu, Y., et al. Hum. Immunol. 71(11):1141-1146(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Grujic, M., et al. J. Immunol. 185(3):1730-1743(2010)Dalla-Costa, R., et al. Hum. Immunol. 71(8):809-817(2010)Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.