|Other Names||Thymic stromal lymphopoietin, TSLP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Isoform 1: Cytokine that induces the release of T-cell- attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells.|
|Tissue Location||Isoform 1 is expressed in a number of tissues including heart, liver and prostate. Isoform 2 is the predominant form in keratinocytes of oral mucosa, skin and in salivary glands It is secreted into saliva.|
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This gene encodes a hemopoietic cytokine proposed tosignal through a heterodimeric receptor complex composed of thethymic stromal lymphopoietin receptor and the IL-7R alpha chain. Itmainly impacts myeloid cells and induces the release of Tcell-attracting chemokines from monocytes and enhances thematuration of CD11c(+) dendritic cells. Alternative splicing ofthis gene results in two transcript variants.
Hunninghake, G.M., et al. Allergy 65(12):1566-1575(2010)Angelova-Fischer, I., et al. J. Invest. Dermatol. 130(10):2505-2507(2010)Smelter, D.F., et al. J. Immunol. 185(5):3035-3040(2010)Wu, W.H., et al. J. Allergy Clin. Immunol. 126(2):290-299(2010)Harada, M., et al. Am. J. Respir. Cell Mol. Biol. (2010) In press :
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